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Novel human leukocyte antigen class I and class II alleles identified by sequence-based typing in the Genetics of Kidneys in Diabetes (GoKinD) study population
Human Immunology, 09/02/09
Cordovado SK et al. – Nine novel HLA class I and class II alleles were identified by sequence–based typing (SBT) in Caucasian participants from the Genetics of Kidneys in Diabetes (GoKinD) study. Eight of these new alleles were identified in participants with type 1 diabetes, three of whom also had diabetic nephropathy, and one new allele was identified in an unaffected parent of a participant with type 1 diabetes. All new alleles were isolated and characterized by use of single allele amplification (SAA) SBT; the new alleles were confirmed by sequence–specific primer (SSP) amplification.
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