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See Latest ArticlesUnderstanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment
Transfusion, 09/09/09
Jackman RP et al. – Donor white blood cells (WBCs) present in transfusion products can lead to immune sequelae such as production of HLA antibodies or graft–versus–host disease in susceptible transfusion recipients. Eliminating the immunogenicity of blood products may prove to be of clinical benefit, particularly in patients requiring multiple transfusions in whom allosensitization is common. The results suggest that defective cell–cell adhesion prevents UV–irradiated cells from inducing T–cell activation.
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