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Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
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Ganguly D et al. – The results demonstrate that the cationic antimicrobial peptide LL37 converts self–RNA into a trigger of TLR7 and TLR8 in human DCs, and provide new insights into the mechanism that drives the auto–inflammatory responses in psoriasis.
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