Allergy/Imm Medical News about hyperalgesia

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Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans
Journal of Neuroinflammation, 08/31/09

Ushida T et al. – Membrane–stabilizing effect and peripheral NMDA–blocking effect possibly produced magnesium–induced mechanical hypesthesia, and extracellular cation–induced sensitization of TRPV1 channels was thought to be the primary mechanism of magnesium–induced heat hyperalgesia.

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