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Kim HN et al. – Immunization with hepatitis B vaccine is recommended for all HIV–infected individuals without immunity to HBV. This patient population, however, has relatively poor HBV vaccine responses. Factors associated with this impaired HBV vaccine response in HIV–infected individuals may include older age, uncontrolled HIV replication, and low nadir CD4 cell count. Postvaccination testing for HBV surface antibody is recommended and vaccine non–responders should undergo repeat immunization with a full series.

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