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Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort
Genes and Immunity, 08/21/09

Amundsen SS et al. – Differential effects of rs6441961*C carrying haplotypes were indicated, and authors thus cannot exclude the possibility that this inability to obtain evidence for multiple independent effects in the CCR1/CCR3/CCR2 gene region was related to a power issue.

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Dr SS Amundsen, 08/24/09

This study confirmed association between celiac disease (CD) and four novel susceptibility gene regions. In addition, a comprehensive association study of the most significantly associated region, 3p21 (CCR1/CCR3/CCR2), revealed association between additional single nucleotide polymorphisms (SNPs) and CD. None of the SNPs displayed associations stronger than the SNP originally identified within this region, rs6441961, nor did any of them add to the effect initially marked by this SNP in a conditional analysis. Differential effects of rs6441961*C carrying haplotypes were however indicated, an observation that most likely did not reach statistical significance due to limited power. Hence, the latter observation could point towards multiple independent effects within the CCR1/CCR3/CCR2 gene region.

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Coeliac disease does not affect visual acuity: A study of young men in the Swedish national conscripts register
Scandinavian Journal of Gastroenterology, 11/06/09 Relevance Score: 68%

Coeliac disease
Australian Family Physician, 10/05/09 Relevance Score: 67%

New link found between osteoporosis and coeliac disease
EurekAlert, 10/08/09 Relevance Score: 66%

Capsule endoscopy in clinical practice: concise up-to-date overview
Clinical and Experimental Gastroenterology, 11/12/09 Relevance Score: 65%

Peptidylarginine deiminases and the pathogenesis of rheumatoid arthritis: A reflection of the involvement of transglutaminase in coeliac disease
European Journal of Internal Medicine, 11/06/09 Relevance Score: 64%