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Goodman WA et al. – T lymphocytes trafficking into lesional psoriatic skin encounter high IL–6 from endothelial cells, DCs, and Th17 cells, enabling cutaneous T cell escape from Treg suppression and Th17 participation in inflammation. Targeting IL–6 signaling pathways in psoriasis may rebalance Treg/T effector activity and ameliorate disease.

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