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See Latest ArticlesNitric oxide cooperates with glucocorticoids in thymic epithelial cell-mediated apoptosis of double positive thymocytes
International Immunology, 08/20/09
Cohen O et al. – Data indicate that a cross–talk between DP thymic cells and TEC is required for proper induction of iNOS–up–regulating cytokines with a subsequent increase in iNOS expression and NO· production in TEC. NO·, in turn, cooperates with GCs in promoting death by neglect. The authors suggest that NO· together with GCs fine–tune the T cell selection process.
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Treatment with the PPAR-gamma agonist rosiglitazone down-regulates interleukin-1 receptor antagonist in individuals with metabolic syndrome
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