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Vaccination of children in low-resource countries against Shigella is unlikely to present an undue risk of reactive arthritis
Vaccine , 08/20/09
Gaston JSH et al. – Clinical trials of candidate Shigella vaccines should be pursued aggressively in the developing world, beginning with a Phase 1 in HLA B27–negative volunteers, but proceeding to Phase 2 and Phase 3 in unscreened volunteers. Post–vaccination monitoring for possible reactive arthritis should be included in all clinical protocols.
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