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Analysis of parathyroid graft rejection suggests alloantigen-specific production of nitric oxide by iNOS-positive intragraft macrophages
Transplant Immunology, 08/27/09

Matuschek A et al. – Intragraft iNOS–positive macrophages seem to be able to produce cytotoxic NO involved in the killing of allogeneic cells during the alloimmune response against primarily nonvascularised parathyroid organ grafts. Infiltrates of iNOS–negative macrophages found in parathyroid isografts were caused by antigen–independent inflammation triggered by surgically induced injury.

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