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Novel humanized anti-CD3 antibodies induce a predominantly immunoregulatory profile in human peripheral blood mononuclear cells
Immunology Letters, 08/21/09
Silva HM et al. – These humanized anti–CD3 antibodies induced a late FOXP3 gene expression while OKT3 led to a more transient expression of FOXP3. Taken this results, authors suggest that these humanized anti–CD3 antibodies may promote the development of T cells with immunoregulatory activity.
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