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TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis
Immunology Letters, 08/21/09
Molano A et al. – The authors have shown that interactions of TWEAK with its receptor Fn14 are instrumental in the pathogenesis of nephritis in the chronic graft–versus–host (cGVH) induced model of lupus. Fn14 is expressed by macrophages and resident kidney cells; authors hypothesized that TWEAK binding to both cell types contributes to the pathogenesis of lupus nephritis.
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