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See Latest ArticlesOsteopontin and the skin: multiple emerging roles in cutaneous biology and pathology
Experimental Dermatology, 08/20/09
Buback F et al. – OPN is secreted in autoimmune diseases such as lupus erythematosus, and influences inflammation of immediate and delayed type allergies and granuloma formation. The authors describe that OPN is overexpressed in psoriasis and propose a model to study OPN function in psoriatic inflammation. Through cytokine functions, OPN supports immune responses against Mycobacteria and viruses such as herpes simplex virus. OPN is also implicated in skin tumor progression. Overexpression of OPN influences invasion and metastasis of melanoma and squamous cell carcinoma cells, and OPN expression in melanoma is a possible prognostic marker.
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Today in Derm Allergy/Immunology...keeping you current
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