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Long-Term Immunogenicity of Two Pediatric Doses of Combined Hepatitis A and B or Monovalent Hepatitis B Vaccine in 8 To 10-Year-Old Children and the Effect of A Challenge Dose Given Seven Years Later
The Pediatric Infectious Disease Journal, 08/13/09
Gilca V et al. – A total of 465 children aged 8 to 10 years were vaccinated with 2 doses of Recombivax–HB 2.5 [mu]g or Twinrix–Junior 10 [mu]g/360 EL.U (TX), according to a 0 and 6 months schedule. Seven years postsecond dose, a challenge dose of vaccine was given. All vaccinees in the TX and 98% in the RB group showed an anamnestic response. Vaccination at the age of 8 to 10 years with two–pediatric doses of TX or RB given with a 6 months interval induces a long–lasting immunity in most vaccinees.
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