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How might infant and paediatric immune responses influence malaria vaccine efficacy
Parasite Immunology, 08/17/09
Moorhann AM – Precisely how age or malaria infections influence the function of these regulators is unknown. Therefore the possibility that infants may not have the immune–dexterity to balance effective parasite clearance with timely immune–regulation leading to protective immunologic memory is considered. And thus, malaria vaccines tested in adults and older children may not be predictive for trials conducted in infants.
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