Allergy/Imm Medical News about cytotoxic T lymphocyte

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Switch from perforin-expressing to perforin-deficient CD8+ T cells accounts for two distinct types of effector cytotoxic T lymphocytes in vivo
Immunology, 08/19/09

Meiraz A et al. – The results show that as the immune response progresses in vivo, targeted cellular suicide mainly prunes high perforin–expressing CD8+ cells, resulting in the gradual switch in effector CTL, from mostly perforin–based to largely Fas/FasL–based killers. Hence, two kinds of CD8+ CTL have two killing strategies.

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