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Timothy grass pollen major allergen Phl p 1 activates respiratory epithelial cells by a non-protease mechanism
Clinical and Experimental Allergy, 08/19/09
Roschmann K et al. – The authors conclude that under physiological conditions Phl p 1 affects tracheal epithelial cells through a non–proteolytic activity. Enhancement of TGF–beta expression induced by Phl p 1 together with the increased release of IL–6 and IL–8 might provide an indirect mechanism through which the allergen may cross the epithelial barrier and attracts immunocompetent cells.
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