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Leukotriene B4 Potentiates CpG Signaling for Enhanced Cytokine Secretion by Human Leukocytes
Journal of Immunology, 08/17/09
Gaudreault E et al. – As observed in neutrophils, PBMC stimulation with LTB4 in the presence of CpG also results in enhanced TAK–1, p38, and JNK phosphorylation/activation. These data provide new evidence underlying the immunomodulatory properties of LTB4 leading to antimicrobial defense.
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