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The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus
Journal of Immunology, 08/11/09
Drennan MB et al. – In this study authors demonstrate that mature iNKT cells are retained in the thymus by the chemokine receptor CXCR3. The authors propose that the expression of CXCR3 ligands in the thymic medullary epithelium promotes the chemotactic retention of mature iNKT thymocytes and prevents leakage of iNKT cells into the peripheral circulation.
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