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Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema
British Journal of Dermatology, 08/17/09
Brown SJ et al. – Filaggrin haploinsufficiency appears to be highly penetrant when all relevant skin features are included in the analysis. FLG null mutations are associated with more severe eczema, but the effect size is small in a population setting.
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