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See Latest ArticlesIdentification of Severe Combined Immunodeficiency by T-Cell Receptor Excision Circles Quantification Using Neonatal Guthrie Cards
The Journal of Pediatrics, 08/12/09
Morinishi Y et al. – TRECs were extremely low in all neonatal Guthrie cards (n=15) and peripheral blood (n=14) from patients with SCID, including those with maternal T–cell engraftment or leaky T cells with hypomorphic RAG1 mutations or LIG4 deficiency. There were no false–positive or negative results in this study. TRECs quantification can be used as a neonatal mass screening for patients with SCID.
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