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See Latest ArticlesPD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells
International Immunology, 08/04/09
Wang W et al. – PD–1 blockade reversed the increased expression of PD–1 and PD–L1 on melanoma antigen–specific CTL by Treg, rescued INF–gamma and IL–2 or INF–gamma and tumor necrosis factor–alpha co–expression and expression of IL–7 receptor by melanoma antigen–specific CTL which were diminished by Treg. PD–1 blockade also resulted in down–regulation of intracellular FoxP3 expression by Treg. These data suggest that PD–1 is importantly implicated in the regulation of Treg function in melanoma patients.
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Factors affecting neutrophil recovery after autologous bone marrow-derived stem cell transplantation in patients with acute myeloid leukemia
Transplantation Proceedings, 11/23/09
Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis
Cancer Research, 11/03/09
Immune Responses in Patients with Metastatic Renal Cell Carcinoma Treated with Dendritic Cells Pulsed with Tumor Lysate
Scandinavian Journal of Immunology, 11/02/09
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