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Arruvito L et al. – The authors found that paternal alloimmunization acts to modulate serum levels of factors involved in the IL–6 trans–signaling pathway and increases the frequency of Treg cells. Consequently, women with reproductive failure show evidence of alteration in the IL–6 trans–signaling pathway which might be associated with abnormal performance of Treg cells in mediating feto–maternal tolerance.

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