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Epigenetic Therapeutics in Autoimmune Disease
Clinical Reviews in Allergy and Immunology, 08/04/09

Szyf M et al. – The prevalence of DNA hypomethylation in lupus suggests that authors should shift the attention from HDAC inhibitors to DNA demethylation inhibitors. MBD2 was recently proposed to be involved in demethylation in T cells in lupus and is, therefore, a candidate target. Although this field is at its infancy, it carries great promise.

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