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Down-Regulation of GRIM-19 Expression is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers
Journal of Interferon & Cytokine Research, 07/31/09
Zhou Y et al. – The authors show that restoration of GRIM–19 levels reestablishes the control over STAT3–dependent gene expression and tumor growth in vivo. GRIM–19 suppressed the expression of tumor invasion– and angiogenesis–associated factors to limit tumor growth. This study identifies another major novel molecular pathway inactivated during the development of human cervical cancer.
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