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Guaraldi G et al. – The primary objective of this study was to evaluate the decreases in IS dosages necessary to maintain an appropriate therapeutic window (TW) after initiating PI–based antiretroviral therapy regimens post–LTx. The overall median time necessary to reach IS TW after dose adjustment was 3.5 days (range 0–15). Unboosted PIs exhibited lesser PK interactions with IS than did RTV–boosted PIs and were thus more amenable to use in the post–LTx setting.

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