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Gonzalez PV et al. – Treatment with alpha–MSH blocked the effect of IL–1 beta on contextual fear memory. Administration of the MC4 receptor antagonist HS014 reversed the effect of alpha–MSH. However, treatment with gamma–MSH, an MC3 agonist, did not affect IL–1 beta–induced impairment of memory consolidation. These results suggest that alpha–MSH, through central MC4R can inhibit the effect of IL–1 beta on memory consolidation.

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