Allergy/Imm Medical News about IgA nephropathy

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Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nephropathy
Nephrology Dialysis Transplantation, 07/24/09

Manno C et al. – The combination of corticosteroids and ramipril may provide additional benefits compared with ramipril alone in preventing the progression of renal disease in proteinuric IgAN patients in the long–term follow–up.

Exclusive Author Commentary
Francesco Paolo Schena, 07/31/09

Immunoglobulin A (IgA) Nephropathy is very common biopsy-proven glomerulonephritis in the world and it is the most common cause of chronic renal failure. Therefore the best treatment for this disease remains to be defined. Schena's group of the University of Bari demonstrated in a randomized controlled clinical trial that the combination of prednisone plus ramipril was able to reduce significantly the risk of renal disease progression after a long-term follow-up of eight years. This is the first report that shows a long-term benefit of therapy in patients with IgA Nephropathy. Therefore these patients have now a long-term therapy for reducing the probability of end-stage kidney failure.

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Renal Cell Carcinoma in Association With IgA Nephropathy in the Elderly
The American Journal of the Medical Sciences, 11/13/09 Relevance Score: 69%

Intrarenal expression of microRNAs in patients with IgA nephropathy
Laboratory Investigation, 11/12/09 Relevance Score: 69%

Parallel Genotyping of 10,204 Single Nucleotide Polymorphisms to Screen for Susceptible Genes for IgA Nephropathy
Annals, Academy of Medicine, Singapore, 11/03/09 Relevance Score: 66%

Leptospirosis and Goodpastures syndrome: testing the aetiological hypothesis
Annals of Tropical Medicine and Parasitology, 11/02/09 Relevance Score: 64%

Nephropathy in Type 1 diabetes is associated with increased circulating activated platelets and platelet hyperreactivity
Platelets, 10/30/09 Relevance Score: 46%