Allergy/Imm Medical News about Rheumatoid arthritis, Treg, DAS28

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Quantification and phenotype of regulatory T cells in rheumatoid arthritis according to Disease Activity Score-28
Autoimmunity, 07/23/09

Sempere-Ortells JM et al. – Study demonstrates that most of changes in regulatory T cell (Treg) parallel the intensity of inflammation, with lowest or highest values in rheumatoid arthritis (RA) patients with moderately/very active disease vs healthy controls and pts with inactive RA. The balance between these cell subsets and their antigen expression determines the inflammation levels; could be linked to the relapsing/remission periods of the disease.

Methods

Study examines the different peripheral blood (PB) Treg subsets in RA pts to test the hypothesis that changes in these cells can be linked to the degree of inflammation and relapsing/remission periods
RA subjects (n=60) with different DAS28 and healthy controls (n=40)
Frequencies of Treg subsets expressing characteristic membrane antigens, FoxP3 or intracellular cytokines were quantified by flow cytometry

Results

A decrease in % of CD4+CD25^high, CD4+CD25^int, CD4+CD25^int/highFoxP3+, CD4+CD38+, CD4+CD62L+, CD8+CD25^highCD45RA+ and CD8+CD25^intCD45RA+ T cells in PB of RA pts vs healthy controls
In addition, increased % of cells expressing membrane/intracellular regulatory antigens such as OX40 (CD134), CD45RB^lowor CTLA-4 (CD152)
A higher proportion of other T cell subsets including CD4+CTLA-4+, CD4+IL10+, CD4+CD25^intIL10+, CD4+CD25^intTGFβ+, CD4+CD25^lowTGFβ+ and CD8+CD28-