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A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury
International Immunology, 07/23/09
Simone R et al. – These results strongly suggest a regulation of sCTLA–4 synthesis depending on the presence or absence of dietary gluten and imply a possible immunomodulatory effect on cytotoxic T lymphocyte functions. In gluten–exposed patients, serum sCTLA–4 levels might provide insight about mucosal injury.
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