Allergy/Imm Medical News about Keratinocytes

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A Central Role for Transcription Factor C/EBP-beta in Regulating CD1d Gene Expression in Human Keratinocytes
Journal of Immunology, 07/27/09

Sikder H et al. – The authors show here that transcription factor C/EBP–beta binds to the CCAAT box in the CD1d promoter in vitro and in vivo. Consistent with these observations, deletion of the gene encoding for C/EBP–beta caused a loss of CD1d expression. The in vivo regulation of CD1d has significant implications for the pathologic mechanisms of certain immunologic skin diseases in which NKT cells play a role, such as allergic contact dermatitis and psoriasis.

Exclusive Author Commentary
Dr. Anthony Gaspari, 07/27/09

This is the first demonstration that this transcription factor plays an important role in regulating CD1d, which in turn controls antigen presentation to invariant NKT-cells. This transcription factor was important in both bone marrow antigen presenting cells (monocytes) as well as epithelial cells (keratinocytes). It presents a new pharmacologic target for controlling inflammation mediated by innate immunity.

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