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Tissue-Specific Abundance of Regulatory T Cells Correlates with CD8+ T Cell Dysfunction and Chronic Retrovirus Loads
Journal of Immunology, 07/23/09
Myers L et al. – The functional phenotype of the virus–specific CD8+ T cells correlated with a 10–fold reduction of chronic Friend virus levels in the liver compared with the spleen. Thus, suppression of CD8+ T cells by virus–induced Tregs occurs in a tissue–specific manner and correlates with profound effects on localized levels of chronic infection.
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Today in Basic Science/Genetics...keeping you current
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Roles of IKK-[beta], IRF1, and p65 in the Activation of Chemokine Genes by Interferon-[gamma]
Journal of Interferon & Cytokine Research, 12/07/09
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Today in Gastrointestinal/Hepatic...keeping you current
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Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels
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