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See Latest ArticlesCurrent understanding of the genetic basis of psoriasis
Expert Review of Clinical Immunology, 07/14/09
Gudjonsson JE et al. - Although it is now generally accepted that psoriatic lesions are caused by abnormal reactivity of specific T cells in the skin, these findings suggest that alterations in the epidermal barrier, innate defenses and processing of inflammatory signals may all contribute to the triggering of nonspecific innate immune mechanisms, which, in combination with altered IL-23 signaling, may lead to the dysregulation of T-cell-driven immune responses.
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Temperature modulated histamine-itch in lesional and nonlesional skin in atopic eczema a combined psychophysical and neuroimaging study
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