Allergy/Imm Medical News about Acute Humoral Rejection

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Acute Humoral Rejection in Renal Allograft Recipients: I. Incidence, Serology and Clinical Characteristics
Transplantation, 07/20/09

Crespo M et al. – More than one–third of the patients with steroid–insensitive AR had evidence of AHR, often resistant to antilymphocyte therapy. Most cases (95%) with DSA at the time of rejection had widespread C4d deposits in peritubular capillaries, suggesting a pathogenic role of the circulating alloantibody. Combined DSA testing and C4d staining provides a useful approach for the early diagnosis of AHR, a condition that often necessitates a more intensive therapeutic rescue regimen.

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