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See Latest ArticlesAddition of long-acting beta-agonists to inhaled corticosteroids for chronic asthma in children
Cochrane Reviews, 07/09/09
Chroinin MN et al. - Most consensus statements recommend the use of long-acting ß2-agonists (LABA) as adjunct therapy to inhaled corticosteroids for poorly controlled asthma. The purpose of this review was to identify the benefits and safety profile of adding long-acting ß2-agonists to inhaled corticosteroids in asthmatic children. Based on the identified paediatric randomised trials, the addition of long-acting ß2-agonists did not significantly reduce the risk of asthma exacerbations requiring rescue systemic steroids, but improved lung function compared to ongoing treatment with a similar dose of inhaled corticosteroids. There was no evidence of increased serious side effects or withdrawals with the addition of long-acting ß2-agonists. Compared to doubling the dose of inhaled corticosteroids, the combination of LABA and inhaled steroids did not lead to a significant reduction in the rate of moderate exacerbations or hospital admissions, but it improved lung function and lead to greater growth.
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Effects of endogenous glucocorticoids on allergic inflammation and TH1/TH2 balance in airway allergic disease
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Detection and home management of worsening asthma symptoms
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