Allergy/Imm

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Steady-state dendritic cells continuously inactivate T cells that escape thymic negative selection
Immunology & Cell Biology, 07/08/09

Doan T et al. - After adult thymectomy, OVA257-264-reactive T cells declined in the periphery indicating that the repertoire of OVA257-264-specific T cells that escaped negative selection and egressed to the periphery, were susceptible to inactivation by steady-state peripheral DC. Thus, in the face of inefficient negative selection, peripheral tolerance induction to cognate antigen by resting DC is a crucial requirement for the inactivation of a self-specific repertoire.

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