Allergy/Imm Medical News about Rheumatoid arthritis, TGF-beta1, Sjogren's syndrome

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Relationship between serum levels of TGF-beta 1 and clinical parameters in patients with rheumatoid arthritis and Sjogren's syndrome secondary to rheumatoid arthritis
Autoimmunity, 07/20/09

Mieliauskaite D et al. - Findings suggest that serum levels of TGF-β1 (a pleiotropic cytokine, which prevents inappropriate autoimmune responses) may reflect ongoing autoimmune inflammation and correlate with joint damage in rheumatoid arthritis (RA).

Methods

Study aims to investigate:
- Serum levels of TGF-β1, and
- Relationship between TGF-β1 and clinical parameters
  in pts with RA and Sjogren's syndrome (SS) secondary to RA (SS + RA)

Results

Comparison of the serum levels of TGF-β1 in pts with RA, SS + RA and NHD differed significantly
Correlations between TGF-β1 levels and radiologically defined joint damage, symptoms and signs of SS was found

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