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See Latest ArticlesBoth early and late apoptotic blebs are taken up by DC and induce IL-6 production
Autoimmunity, 07/17/09
Fransen JH et al. – Both forms of blebs contain apo–induced chromatin modifications and are efficiently phagocytosed by dendritic cell (DC). Uptake by DC of late, but also early apo blebs, stimulate DC to produce IL–6. This bleb–induced effect on DC may be an important step in the initiation of the autoimmune responses in SLE.
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