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Castiglioni MT et al. - Patients with pre-existing nephropathy, a well-characterized microvascular complication of diabetes, have even higher PTX3 concentrations and worse maternal and fetal outcomes. Six/thirty-four diabetic non-nephropatic patients developed PEc: PTX3 levels rose abruptly weeks before PEc manifested. PTX3 may represent a valuable marker for early detection and prediction of PEc in patients with T1DM.

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