Allergy/Imm Medical News about CRP, SLE, Vascular disease

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C-reactive protein in systemic lupus erythematosus
Autoimmunity, 07/08/09

Batuca J et al. – Article outlines the multiple roles of C-reactive protein (CRP) in the pathogenesis of auto-immune and inflammatory responses, making it an important tool in the clinical management of patients.

CRP activates the classical complement pathway in a controlled fashion, enhancing the capacity for defence against bacterial infections
It plays a protective role against pathogenic autoimmune responses in general, and systemic lupus erythematosus in particular
CRP is also associated with atherosclerosis, both in the general population and in different auto-immune conditions
It plays a double role as a biomarker for vascular risk and as an independent risk factor as it can also perpetuate the inflammatory response

As a marker of increased inflammation and as a risk factor for further disease activity and damage, CRP is a crucial factor in the understanding of the pathogenesis of vascular disease as well as in the clinical management of patients with and without SLE.

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Longitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus
Atherosclerosis, 10/08/09 Relevance Score: 88%

Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in SLE patients
Clinical Rheumatology, 11/17/09 Relevance Score: 82%

Circulating surfactant protein D is decreased in systemic lupus erythematosus
Journal of Rheumatology, 10/19/09 Relevance Score: 80%

The phenotypic profile of dermatomyositis and lupus erythematosus: a comparative analysis
Journal of Cutaneous Pathology, 11/06/09 Relevance Score: 78%

Associations of very high C-reactive protein concentration with psychosocial and cardiovascular risk factors in an ageing population
Atherosclerosis, 10/13/09 Relevance Score: 78%