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See Latest ArticlesNph, DC and chromatin-mediated pathogenesis in systemic lupus erythematosus
Autoimmunity, 07/13/09
Lindau D et al. - The elevated concentrations and the immunostimulatory capacities of circulating Nuc may favour the break of peripheral tolerance in genetically predisposed individuals. Nevertheless, in most cases the signalling pathways involved are not elucidated yet, although Tir8/Sigirr deficiency has been recently shown to enhance cell activation upon exposure to Nuc-containing immune complexes.
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