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VAMP8 Is Essential in Anaphylatoxin-Induced Degranulation, TNF-alpha Secretion, Peritonitis, and Systemic Inflammation
Journal of Immunology, 07/07/09
Pushparaj PN et al. - These data demonstrate that the VAMP8 vesicle-associated-SNARE is required for the proper trafficking of secretory lysosomal granules for exocytosis in macrophages and for the release of the potent proinflammatory cytokine, TNF-alpha.
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