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Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-alpha on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP
Journal of Immunology, 07/15/09
Kunisch E et al. - Although specific blockade of EP2 receptors is considered a promising therapeutic strategy in RA, opposite regulation of proinflammatory IL-6 and prodestructive MMP-1 by PGE2 via EP2 may require more complex approaches to successfully inhibit the cyclooxygenase-1/2 cAMP axis.
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Autoantibodies against C1q in Systemic Lupus Erythematosus Are Antigen-Driven
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