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The effects of corticosteroids on bone growth and bone density
Annals of Allergy, Asthma, and Immunology, 07/06/09
Weldon D – Study suggests that preventing corticosteroid-induced effects on bone metabolism can allow effective treatment of allergic disease without long-term adverse effects.
Methods- Main objectives of this study were to define the effects of both parenteral and inhaled corticosteroids on:
- Bone growth in children and
- Development of osteopenia and osteoporosis in children and adults
- Articles in PubMed and MEDLINE published from 1983 to 2008 were searched
- Keywords: corticosteroids and bone growth, osteopenia, osteoporosis, and bisphosphonates
- Publications reviewed include randomized, placebo-controlled studies of both children and adults
- Because systemic and high-dose inhaled corticosteroids affect bone growth of children taking these medications, stadiometry should be used to measure the growth of children
- Osteoporosis due to repetitive courses of oral or parenteral corticosteroids and inhaled corticosteroids can develop gradually in aging adult
- Prophylaxis against osteoporosis requires:
- An index of suspicion
- Assessment of bone density
- Supplemental calcium and vit D, and
- Use of bisphosphonates
- to prevent bone fractures that could compromise the pt's quality of life
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