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Immunogenicity of Anti-TNF-alpha Agents in Autoimmune Diseases
Clinical Reviews in Allergy and Immunology, 07/06/09

Aikaw NE et al. - The use of etanercept was associated to the development of anti-etanercept antibodies in 0% to 18% of patients, without apparent effect on effectiveness or adverse events. Studies with RA and CD patients show prevalence of anti-adalimumab antibodies from 1% to 87%. Immunosuppressive drug addiction can reduce the induction of anti-TNF-alpha antibodies.

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