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See Latest ArticlesBicarbonate induces Vibrio cholerae virulence gene expression by enhancing ToxT activity
Infection and Immunity, 07/01/09
Abuaita BH et al. - Ethoxyzolamide, a potent carbonic anhydrase inhibitor, inhibits bicarbonate- mediated virulence induction, suggesting that conversion of CO2 into bicarbonate by carbonic anhydrase plays a role in virulence induction. Thus, bicarbonate is the first positive effector for ToxT activity to be identified. Given that bicarbonate is present at high concentration in the upper small intestine where V. cholerae colonizes, bicarbonate is likely an important chemical stimulus that V. cholerae senses to induce virulence during the natural course of infection.
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