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B cells and aging: molecules and mechanisms
Trends in Immunology, 07/01/09
Cancro MP et al. - Reductions in gene products crucial for immunoglobulin class switch recombination and somatic hypermutation impact the efficacy of humoral immune responses. Together, these findings set the stage for integrated analyses of how age-related changes at the molecular, cellular and population levels interact to yield the overall aging phenotype.
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