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Gold nanoparticle enhanced immuno-PCR for ultrasensitive detection of Hantaan virus nucleocapsid protein
Journal of Immunological Methods, 06/29/09
Chen L et al. - The detection limit of this method could reach down to 10 fg/mL for detecting purified HNP in buffers as well as in human serum, which was - 7 orders of magnitude more sensitive than that of conventional ELISA. The current assay format might be adopted for other proteins that need ultra-high sensitive detection.
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