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Serum factors potentiate hypoxia-induced hepatotoxicity in vitro through increasing transforming growth factor-beta 1 activation and release
Cytokine, 06/26/09
Kao YH et al. - The results suggest that the mechanism governing TGF-beta activation plays a crucial role in hypoxia-induced hepatotoxicity. Thus, interventions on TGF-beta 1 bioavailability and/or its cognate signaling may be of benefit in preventing hypoxia-related liver injuries.
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