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See Latest ArticlesApex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
International Immunology, 06/26/09
Sabouri Z et al. - Results suggest that Apex2 may play a critical role in SHM through its 3'–5' exonuclease activity. Unexpectedly, the efficiency of CSR was not reduced in Apex2-deficient B cells. In addition, Apex1 knockdown in CH12F3-2 B lymphoma cells did not affect the CSR frequency, suggesting that neither Apex1 nor Apex2 plays a major role in CSR.
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